Custom Monoclonal Antibody Development Services

Cutting-edge science requires reliable, validated antibodies against your specific target. Sometimes, these aren’t available off the shelf. At Fortis Life Sciences®, we offer recombinant monoclonal antibody development services supported by a team with over 50 years of antibody development and manufacturing experience.

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Scientist Extracting a Rack Tube With Urine Samples. Closeup of a Scientist Working With Urine Samples in Lab.

A White Glove Experience

We deliver a concierge service from project design through to delivery of your custom antibody. Beginning with detailed discussions to understand your project goals, our technical team works with you to craft an antibody development plan that meets your needs.

Pricing and milestones are established following detailed discussions regarding the scope of work, including:

  • Target
  • Design goals
  • Deliverables

Antigens Designed and Purified In-House

We purify native antigens and produce both recombinant proteins and synthetic peptides in-house. That means we have complete control over their design and QC. And because we make our recombinant protein antigens, we can target proteins and protein isoforms that may otherwise not be commercially available.

Our scientists excel at making custom antibodies to:

  • Cell surface, secreted, and intracellular targets
  • Anti-idiotype antibodies
  • Post-translational modifications (phospho-specific antibodies)
  • Small molecules

Recombinant Monoclonal Antibodies

All projects utilize target-specific B cell selection, which yields robust numbers of recombinant rabbit monoclonal antibody candidates for screening. Our robust monoclonal antibody generation platform delivers diverse clone sets, enabling you to discover and validate fit-for-purpose monoclonal antibodies.

Design goals may include:

  • Performance in western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation ELISA, or flow cytometry
  • Epitope binning to find compatible pairs of antibodies

Milestone-based Project Design

Our milestone design puts you in control of your custom antibody development project. We generate numerous candidates for you to test in your own assays and you tell us which clones work the way you need them to. This strategy reduces the risk of failures and expensive repeats, stacking the deck as heavily as possible in your favor.

Deliverables may include:

  • Recombinant rabbit monoclonal antibody that performs in the desired application(s)
  • The formulation and scale you need from milligrams to grams
  • Shortest possible timeline to meet your deadline

Our Areas of Expertise

Target Types

Cell surface, secreted and intracellular targets

Anti-idiotype antibodies

Post-translational modifications
(Phospho-specific
antibodies)

Small molecules


Additional Services

Binding pair selection by competition binning

Monoclonal antibody reformatting


Antibody Generation Process

A timeline of the Fortis custom monoclonal antibody generation process. Milestone 1 takes approximately 3 months and includes client consultations, antigen design and production by the client or by Fortis, immunization, and single B cell isolation and screening. Cloning and expressing micrograms of the recombinant monoclonal antibodies takes less than one month and is milestone 2. Then, the client performs fit-for-purpose testing of the clone sets. Scaling up of the client-selected clones to milligram levels, to reach milestone 3, takes less than 2 months. Finally, Fortis can provide an ongoing supply of the antibody.

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Learn How Our Customers Are Leveraging Bethyl Custom Antibody Services

"We’ve been consistently pleased by Fortis’s initial candidate success rate. We’re now engaged in multiple projects with Fortis, with several anti-PTM clones about to be launched as formal genomic mapping reagents."

Michael-Christopher Keogh, PhD
Chief Scientific Officer
EpiCypher Inc.


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"Some companies only splenectomize and proceed with one rabbit, whereas Fortis immunizes multiple rabbits, and these are all screened for antibodies to provide a distribution of the best potential candidates. In this way, we receive multiple options for performing our own screens."

Lori Kobayashi
Project Manager
Valted Seq


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"The whole process has been very easy, because Fortis cloned each B cell, enabling it to produce more antibodies and generate high yields."

Bijan Etemad-Gilbertson, PhD
Head of Antibody Technology
NextPoint Therapeutics


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Submit Your Custom Monoclonal Antibody Request


The Fortis Life Sciences Difference

  • High Quality Products
  • Leading Technical Support
  • One-day Shipping on 95% of Products

Fortis is dedicated to supporting scientific discovery through its qualified antibody products and custom polyclonal antibody service, and serves to advance science by developing qualified antibodies for emerging and underserved protein targets.

Our portfolio consists of over 9,500 catalog products, offering over 8,000 primary antibodies, targeting over 3,000 proteins and 1,000 secondary antibodies raised against immunoglobulins from over 25 species.

Bethyl Laboratories has been a provider of qualified antibody products and custom services since it was founded in 1972. Bethyl Laboratories is now part of Fortis Life Sciences. Learn more here.

Fortis is committed to the welfare of animals as reflected by the company’s core values. As a USDA-registered research facility, our practices strictly adhere to the Animal Welfare Act.

USDA Class R Research Facility Registration #74-R-0044
PHS/NIH/OLAW Animal Welfare #A3991-01