A Diagnostic Device for Detecting Biomarkers of Organ Injury in Saliva
Organ injury – arising from diverse causes such as heart attack, chemical exposure, and other factors – induces biochemical changes in the human body that can be directly measured. The ability to detect and quantify relevant biomarkers associated with organ damage without invasive blood collection holds immense value when such events occur outside of a clinical setting.
Saliva-based lateral flow diagnostics are attractive due to low cost, rapid results, and the low-invasive nature of specimen collection, but developing such tests faces challenges associated with both biomarker prevalence – relevant markers in saliva can be 1000-fold less concentrated than they are in blood – and there may be high concentrations of dissolved solids, such as mucins, which interfere with the controlled flow required for assays based on capillary draw.
This presentation by Dr. Aaron Saunders, Director of Research & Development at Fortis Life Sciences, will cover the development of saliva-based lateral flow assays for the detection of biomarkers associated with organ damage and present innovative solutions to address challenges, including refining on-strip chemistry for flow control, novel magnetic-plasmonic reporter particles for heightened sensitivity and sample concentration, and tailored housings for precise magnet-based control during particle introduction.
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