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Design and Optimization of Mouse Markers for Use in Melanoma, Cardiac Applications

Learn about the optimization of spatial biology panels for studying mouse tissues.

As one of the fastest growing cancers globally, melanoma research generates a significant amount of interest. Metastatic melanoma, specifically, drives the need for more diverse therapeutic approaches as surgery alone is often not enough. Targeted immunotherapies are increasing as a result to combat these difficult to treat cancers and monoclonal antibody production is subsequently becoming more important.

Spatial biology of human tissues has escalated in recent years, leading to many novel discoveries. However, available tools for multiplexing have evolved at a slower pace, driving the need for diverse biomarkers. As human tissue is precious and often difficult to obtain, the mouse model has become the dominate disease model. Unfortunately, quality human anti-mouse antibodies are still lacking in many research areas.

Here we examine the ability of our rabbit antibodies to detect mouse protein in multiplex IHC experiments. Rabbit antibodies, which are either designed for mouse targets or cross-react with mouse targets, are effective reagents to develop mouse multiplex panels.

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