Nanomolar VHH binders of PD-L1 and other therapeutic targets from the AbNano™ VHH Naive Library
VHH domains, derived from the variable heavy chain of the heavy-chain-only IgG2 and IgG3 domains in camelids, represent a small, single-domain antibody fragment. VHH domains have been successfully applied to technologies such as bispecific therapeutic molecules.
Discovering novel VHH domains can take place by multiple workflows, including using B-cell sorting and using display libraries. Within display libraries, the library is generally one of three classes of molecule: synthetic molecules, immune-derived molecules, or naïve germline molecules.
Each approach has its own unique advantages and applications. Here, we present the construction and early validation of a large naïve library from llamas and alpacas. The data suggests that this library, the AbNano™ VHH Naïve Library, may be well-suited for rapid discovery of VHH domains binding to therapeutic targets with varying levels of affinity.
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