Mouse anti-p53 Monoclonal Antibody Purified [DO-1]
Catalog #
p53
Human
Flow Cyt
,IHC
,IP
,WB
COMET™
Mouse
Monoclonal
DO-1
Whole IgG
Recombinant full length protein corresponding to Human p53 (N terminal). epitope is within aa 20-25
IgG2a
Unconjugated
Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Tris-buffered Saline containing 0.09% Sodium Azide, BSA-Free
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The antibody was purified from mouse hybridoma (DO-1) conditioned media.
p53 is a tumor suppressor protein that is mutated or inactivated in over 50% of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis.
Alternate Names
antigen NY-CO-13; BCC7; cellular tumor antigen p53; LFS1; mutant tumor protein 53; P53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; TRP53; tumor protein 53; Tumor suppressor p53; tumor supressor p53
Applications