Rabbit anti-Artemis IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00408 maps to a region between residues 650 and the C-terminus (residue 692) of human DNA cross-link repair 1C (aka Artemis) using the numbering given in TrEMBL entry Q96SD1 (GeneID 64421).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to Artemis immobilized on solid support.
The epitope recognized by IHC-00408-T maps to a region between residues 650 and the C-terminus (residue 692) of human DNA cross-link repair 1C (aka Artemis) using the numbering given in TrEMBL entry Q96SD1 (GeneID 64421).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
Artemis is also known as DNA cross-link repair 1C protein (DCLRE1C) and functions as both an endo- and exo-nuclease involved in V(D)J recombination and double-strand break (DSB) repair. In addition to repair of double stranded breaks during V(D)J recombination, Artemis may also be required for repair of ionizing radiation induced DSBs. Mutations in Artemis have been found to be a cause of severe combined immunodeficiency (SCID).
Alternate Names
A-SCID; DCLREC1C; DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae); DNA cross-link repair 1C protein; hSNM1C; protein artemis; Protein A-SCID; RS-SCID; SCIDA; severe combined immunodeficiency, type a (Athabascan); SNM1 homolog C; SNM1C; SNM1-like protein
Applications
Epitope exposure is recommended.
Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.