Rabbit anti-BCCIP IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00636 maps to a region between residue 300 and 350 of human BRCA2 and CDKN1A interacting protein using the numbering given in entry NP_510868.1 (GeneID 56647).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to BCCIP immobilized on solid support.
The epitope recognized by IHC-00636-T maps to a region between residue 300 and 350 of human BRCA2 and CDKN1A interacting protein using the numbering given in entry NP_510868.1 (GeneID 56647).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
BCCIP (BRCA2 and CDKN1A interacting protein) was isolated as a BRCA2 and p21 interacting protein. Downregulation of BCCIP results in chromosome instability and incomplete cytokinesis indicating a role in DNA damage. Additionally, BCCIP is critical for BRCA2- and Rad51-dependent homologous recombinational repair.
Alternate Names
BCCIPalpha; BCCIPbeta; BRCA2 and CDKN1A-interacting protein; BRCA2 and Cip1/p21 interacting protein; cdk inhibitor p21 binding protein; p21- and CDK-associated protein 1; protein TOK-1; TOK1; TOK-1; TOK-1alpha; TOK-1beta
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.