Rabbit anti-BCR IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00406 maps to a region between residue 50 and 100 of human breakpoint cluster region using the numbering given in entry NP_004318.3 (GeneID 613).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to BCR immobilized on solid support.
The epitope recognized by IHC-00406-T maps to a region between residue 50 and 100 of human breakpoint cluster region using the numbering given in entry NP_004318.3 (GeneID 613).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
BCR (breakpoint cluster region) was identified as part of a fusion protein that results from a reciprocal translocation with the ABL gene between chromosomes 22 and 9. The BCR-ABL fusion is the cause of chronic myeloid leukemia (CML). The BCR protein contains a C2 domain, a DBL-homology domain, a PH domain, and a Rho-GAP domain and functions as a GTPase-activating protein for RAC1 and CDC42.
Alternate Names
ALL; BCR/FGFR1 chimera protein; BCR1; breakpoint cluster region; breakpoint cluster region protein; CML; D22S11; D22S662; FGFR1/BCR chimera protein; PHL; renal carcinoma antigen NY-REN-26
Applications
Epitope exposure is recommended for formalin-fixed, paraffin-embedded cells.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.