Rabbit anti-BLM Recombinant Monoclonal Antibody [BLR313M]
Product Details
Specifications
Immunogen was a peptide representing a region between residue 1367 and the C-terminus (residue 1417) of human RecQ-like DNA helicase BLM using the numbering given in entry NP_000048.1 (Gene ID 641).
Additional Product Information
Bloom syndrome protein (BLM) is a RecQ DNA-helicase that plays a role in DNA replication and repair. Mutations and inactivation of BLM result in human syndromes characterized by dwarfism, infertility, erythema, learning disabilities, immune deficiency and predisposition to cancer. BLM has been shown to associate with the BRCA1-associated genome surveillance complex (BASC) which contains BRCA1, MSH2, MSH6, MLH1, ATM, PMS2 and the RAD50-MRE11-NBS1 protein complex.
Alternate Names
Bloom syndrome protein; Bloom syndrome RecQ like helicase; Bloom syndrome, RecQ helicase-like; BS; DNA helicase, RecQ-like type 2; MGRISCE1; recQ protein-like 3; RECQ2; RECQL2; RECQL3