Rabbit anti-CDK2 IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00374 maps to a region between residue 248 and 298 of human cyclin-dependent kinase 2 using the numbering given in entry NP_001789.2 (GeneID 1017).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to CDK2 immobilized on solid support.
The epitope recognized by IHC-00374-T maps to a region between residue 248 and 298 of human cyclin-dependent kinase 2 using the numbering given in entry NP_001789.2 (GeneID 1017).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
Cyclin-dependent kinase 2 (CDK2) is a member of the CDK family of protein kinases that regulate cell cycle progression. CDK2 associates with cyclin E or cyclin A to drive the cell cycle through G1- and S-phase. Substrates of CDK2 include pRb, p53, p27, E2F, Brca1, CDK7, B-Myb, PP1 alpha, RNA Pol II CTD, axin, p220 NPAT, ribonucleotide reductase M2, Myo-D, MARCKS, HsCdc6, and CP110.
Alternate Names
cdc2-related protein kinase; CDKN2; cell division protein kinase 2; cyclin-dependent kinase 2; p33 protein kinase; p33(CDK2)
Applications
Epitope exposure is recommended.
Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.