Rabbit anti-EXOSC4 Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by A303-774A maps to a region between residue 1 and 50 of human EXOSC4, exosome component 4 using the numbering given in entry NP_061910.1 (GeneID 54512).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to EXOSC4 immobilized on solid support.
The epitope recognized by A303-774A-T maps to a region between residue 1 and 50 of human EXOSC4, exosome component 4 using the numbering given in entry NP_061910.1 (GeneID 54512).
Additional Product Information
Exosome component 4 (EXOSC4) is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NPD3].
Alternate Names
exosome complex component RRP41; exosome complex exonuclease RRP41; Exosome component 4; exosome component Rrp41; hRrp41p; p12A; ribosomal RNA-processing protein 41; RRP41; RRP41A; Rrp41p; SKI6; Ski6p
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).
Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.