Rabbit anti-FKBP5/FKBP51 IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00289 maps to a region between residue 407 and 457 of human FK506 binding protein 5 (51 kDa FK506-binding protein) using the numbering given in entry NP_004108.1 (GeneID 2289).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to FKBP5/FKBP51 immobilized on solid support.
The epitope recognized by IHC-00289-T maps to a region between residue 407 and 457 of human FK506 binding protein 5 (51 kDa FK506-binding protein) using the numbering given in entry NP_004108.1 (GeneID 2289).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
FKBP5/FKBP51 is an immunophilin and target of FK506, a macrolide immunosuppressive drug derived from Streptomyces tsukubaensis. Like other FK506 binding proteins, FKBP5/FKBP51 exhibits peptidyl-prolyl cis-trans isomerase activity. The most studied role of FKBP5/FKBP51 surrounds its involvement in the regulation of steroid receptor signaling. In association with the molecular chaperones Hsp90 and Hsp70, FKBP5/FKBP51 is able to influence steroid-hormone binding affinity and transcriptional activity. Recently, FKBP5/FKBP51 has become of interest in the field of psychiatry due to its potential role in cortisol regulation and its relation to mood disorders.
Alternate Names
51 kDa FK506-binding protein; 51 kDa FKBP; 54 kDa progesterone receptor-associated immunophilin; AIG6; androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP51; FKBP-51; FKBP54; HSP90-binding immunophilin; P54; peptidylprolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase FKBP5; PPIase; PPIase FKBP5; Ptg-10; rotamase; T-cell FK506-binding protein
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.