Rabbit anti-FMR1/FMRP Antibody Affinity Purified
Product Details
Specifications
Additional Product Information
Fragile X mental retardation protein 1 is the product of the gene FMR1, also known as FMRP. This protein binds RNA and is associated with polysomes. FMRP may also be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1).
Alternate Names
FMRP; fragile X mental retardation protein 1; FRAXA; POF; POF1; Protein FMR-1; synaptic functional regulator FMR1
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).
Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.