Rabbit anti-FOG1/ZFPM1 IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00369 maps to a region between residue 175 and 225 of human friend of GATA-1 (zinc finger protein, multitype 1) using the numbering given in entry NP_722520.2 (GeneID 161882).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to FOG1/ZFPM1 immobilized on solid support.
The epitope recognized by IHC-00369-T maps to a region between residue 175 and 225 of human friend of GATA-1 (zinc finger protein, multitype 1) using the numbering given in entry NP_722520.2 (GeneID 161882).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
FOG1/ZFPM1 was identified in a yeast two-hybrid screen for GATA-1 interacting proteins. GATA-1 is zinc finger transcription factor whose expression is restricted to hematopoietic cells and plays and essential role in erythroid development. FOG1/ZFPM1 is highly expressed in erythroid cells and megakaryocytes and appears to play both a GATA-1-dependent and -independent role in erythropoiesis and megakaryopoiesis. FOG1/ZFPM1 associates with GATA-1 as well as GATA-2 and GATA-3 as a heterodimer to activate or repress transcription.
Alternate Names
FOG; FOG1; FOG-1; friend of GATA 1; friend of GATA protein 1; ZC2HC11A; zinc finger protein 89A; Zinc finger protein multitype 1; zinc finger protein ZFPM1; zinc finger protein, multitype 1; ZNF408; ZNF89A
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.