Rabbit anti-GTF2I/TFII-I IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00273 maps to a region between residue 985 and 998 of human general transcription factor II-I using the numbering given in entry NP_127492.1 (GeneID 2969).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to GTF2I/TFII-I immobilized on solid support.
The epitope recognized by IHC-00273-T maps to a region between residue 985 and 998 of human general transcription factor II-I using the numbering given in entry NP_127492.1 (GeneID 2969).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
GTF2I/TFII-I is a multi-functional transcription factor that interacts with the basal transcription machinery and links upstream cellular signals to responsive activator complexes that associate with the C-FOS promoter and other response elements. Haploinsufficiency of GTF2I/TFII-I results in Williams-Beuren syndrome (WBS), a rare developmental disorder characterized by musculo-skeletal and cardiac abnormalities.
Alternate Names
BAP135; BAP-135; Bruton tyrosine kinase-associated protein 135; BTKAP1; BTK-associated protein 135; BTK-associated protein, 135kD; DIWS; general transcription factor II-I; GTFII-I; IB291; SPIN; SRF-Phox1-interacting protein; TFII-I; WBS; WBSCR6; Williams-Beuren syndrome chromosomal region 6 protein; Williams-Beuren syndrome chromosome region 6
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.