Rabbit anti-LDLR Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by A304-417A-T maps to a region between residue 810 to 860 of human Low Density Lipoprotein Receptor using the numbering given in entry NP_000518.1 (GeneID 3949).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to LDLR immobilized on solid support.
The epitope recognized by A304-417A maps to a region between residue 810 to 860 of human Low Density Lipoprotein Receptor using the numbering given in entry NP_000518.1 (GeneID 3949).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
Low-density lipoprotein receptor, LDLR, binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, LDLR functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cell [taken from NCBI Entrez Gene (Gene ID: 3949)].
Alternate Names
FH; FHC; LDL receptor; LDLCQ2; low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.