Rabbit anti-MSH2 IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00082 maps to a region between residue 875 and the C-terminus (residue 934) of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436). Antibody was affinity purified using an epitope specific to MSH2 immobilized on solid support.
The epitope recognized by IHC-00082-T maps to a region between residue 875 and the C-terminus (residue 934) of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436).
Additional Product Information
MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC).
Alternate Names
COCA1; DNA mismatch repair protein Msh2; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2
Applications
Epitope exposure is recommended.