Bethyl Laboratories® Rabbit anti-Notch1 IHC Antibody, Affinity Purified - 100 µl (50+ slides)
Product Details
Specifications
Additional Product Information
Notch1 is the human homolog of the D. melanogaster Notch gene first reported as the gene responsible for the presence of notches in the wingblades of a specific strain of flies. The Notch protein is a transmembrane receptor that mediates juxtacrine signals between adjacent cells. Mammalian Notch1 ligands include Delta-like and Jagged. Upon ligand binding, Notch1 undergoes two proteolytic cleavage events that result in the release of the intracellular Notch1 domain and its translocation to the nucleus where it can participate in gene transactivation. Notch 1 signals mediate cellular fate, differentiation, and development.
Alternate Names
AOS5; AOVD1; hN1; neurogenic locus notch homolog protein 1; Notch 1; Notch homolog 1, translocation-associated; TAN1; translocation-associated notch protein TAN-1
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.