Rabbit anti-OSR1 IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00552 maps to a region between residue 375 and 425 of human oxidative-stress responsive 1 using the numbering given in entry NP_005100.1 (GeneID 9943).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to OSR1 immobilized on solid support.
The epitope recognized by IHC-00552-T maps to a region between residue 375 and 425 of human oxidative-stress responsive 1 using the numbering given in entry NP_005100.1 (GeneID 9943).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
Oxidative stress responsive 1 (OSR1) is a STE20-related kinase involved in ion transport and fluid and ion homeostasis. OSR1 interacts with SPAK (STE20/SPS1-reated proline/alanine-rich kinase) and together are activated by the upstream kinase WNK1 [with no K (lysine) protein kinase-1]. Activation of OSR1 and SPAK by WNK1 results in the phosphorylation and activation of NKCC1 (Na+-K+-2Cl- co-transporter 1) for the control of cell volume and blood pressure.
Alternate Names
OSR1; oxidative stress-responsive 1 protein; serine/threonine-protein kinase OSR1
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.