Rabbit anti-PALB2 IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00251 maps to a region between residue 200 and 250 of human partner and localizer of BRCA2 using the numbering given in entry NP_078951.2 (GeneID 79728).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to PALB2 immobilized on solid support.
The epitope recognized by IHC-00251-T maps to a region between residue 200 and 250 of human partner and localizer of BRCA2 using the numbering given in entry NP_078951.2 (GeneID 79728).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
PALB2 (partner and localizer of BRCA2) interacts with BRCA2 and promotes BRCA2 localization and stability. PALB2 is also known as FANCN. Bi-allelic mutations in PALB2 result in Fanconi anemia disorder and breast cancer susceptibility. At the cellular level, PALB2 is important to the DNA damage response and chromosome stability and is essential to BRCA2 function.
Alternate Names
FANCN; mutant partner and localizer of BRCA2; partner and localizer of BRCA2; PNCA3
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.