Rabbit anti-PD-L1 Recombinant Monoclonal Antibody [BLR020E]
Catalog #
PD-L1
Human
Flow Cyt
,ICC-IF
,IHC
,IHC-IF
,IP
,mIF
,WB
COMET™
,PhenoImager™ HT
Rabbit
Recombinant Monoclonal
BLR020E
Whole IgG
Between 240 and C-terminus
IgG
Unconjugated
Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide
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Borate Buffered Saline (BBS) pH 8.2 with 0.09% Sodium Azide, BSA-Free
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Recombinant antibody was purified from cell culture supernatant.
Immunogen was a synthetic peptide representing a region between residue 250 and the C-terminus (residue 290) of human programmed cell death 1 ligand 1 (PD-L1) according to the numbering given in entry NP_054862.1 (GeneID 29126).
PD-L1 is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma [taken from NCBI Entrez Gene (Gene ID: 55193)].
Alternate Names
B7 homolog 1; B7-H; B7H1; B7-H1; CD antigen CD274; CD274 antigen; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; programmed cell death 1 ligand 1; Programmed death ligand 1
Applications