Rabbit anti-Rad50 IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00076 maps to a region between residue 700 and 750 of human Rad50 using the numbering given in entry NP_005723.2 (GeneID 10111). Antibody was affinity purified using an epitope specific to Rad50 immobilized on solid support.
The epitope recognized by IHC-00076-T maps to a region between residue 700 and 750 of human Rad50 using the numbering given in entry NP_005723.2 (GeneID 10111).
Additional Product Information
Rad50 is a component of the Mre11-Rad50-Nbs1 (MRN) complex that repairs DNA double strand breaks during DNA damage and homologous recombination and activates the S-phase checkpoint. Rad50 shows structural similarity to the structural maintenance of chromosomes (SMC) family of proteins. Rad50 has been shown to directly interact with BRCA2, TERF2IP, and ATM.
Alternate Names
DNA repair protein RAD50; hRad50; NBSLD; RAD50 homolog, double strand break repair protein; RAD502
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.