Rabbit anti-SMC6 IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00198 maps to a region between residues 1050 and the C-terminus (residue 1091) of human Structural Maintenance of Chromosomes 6 using the numbering given in TrEMBL entry Q96SB8 (GeneID 79677). Antibody was affinity purified using an epitope specific to SMC6 immobilized on solid support.
The epitope recognized by IHC-00198-T maps to a region between residues 1050 and the C-terminus (residue 1091) of human Structural Maintenance of Chromosomes 6 using the numbering given in TrEMBL entry Q96SB8 (GeneID 79677).
Additional Product Information
SMC (Structural maintenance of chromosomes) proteins are members of multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. Two of these complexes, cohesin and condensin consist of a core complex of an SMC1 and SMC3 heterodimer or an SMC2 and SMC4 heterodimer, respectively. A third complex includes a heterodimer of SMC5 and SMC6 whose function is not fully understood but is proposed to be related to DNA repair.
Alternate Names
hSMC6; SMC protein 6; SMC-6; SMC6 structural maintenance of chromosomes 6-like 1; SMC6L1; structural maintenance of chromosomes protein 6
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.