Rabbit anti-SMN1 Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by A301-862A maps to a region between residue 50 and 100 of human survival of motor neuron 1 using the numbering given in entry NP_000335.1 (GeneID 6606).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to SMN1 immobilized on solid support.
The epitope recognized by A301-862A-T maps to a region between residue 50 and 100 of human survival of motor neuron 1 using the numbering given in entry NP_000335.1 (GeneID 6606).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
Survival motor neuron protein (SMN1) has been identified as the gene that is defective in spinal muscular atrophy (SMA), a neurodegenerative autosomal recessive disease characterized by paralysis and muscular atrophy which results from the loss of motor neurons in the spinal cord. There are two closely related SMN genes that do not appear to be functionally redundant. SMN1 represents the telomeric copy while SMN2 represents the centromeric copy. In the cell, SMN1 is part of a large complex of proteins involved in snRNP biogenesis. The functional role of SMN1 is proposed to play a role in messenger and ribosomal RNA transcription and processing.
Alternate Names
BCD541; component of gems 1; GEMIN1; gemin-1; SMA; SMA@; SMA1; SMA2; SMA3; SMA4; SMN; SMNT; survival motor neuron 1 protein; survival motor neuron protein; T-BCD541; TDRD16A; tudor domain containing 16A
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.