Rabbit anti-XLF IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00185 maps to a region between residues 200 and 250 of human XRCC4-Like Factor using the numbering given in entry NP_079058.1 (GeneID 79840). Antibody was affinity purified using an epitope specific to XLF immobilized on solid support.
The epitope recognized by IHC-00185-T maps to a region between residues 200 and 250 of human XRCC4-Like Factor using the numbering given in entry NP_079058.1 (GeneID 79840).
Additional Product Information
XRCC4-like factor (XLF) functions in DNA nonhomologous end joining (NHEJ) in double-strand break repair and immune system V(D)J recombination. Mutations of XLF in humans have been documented to result in immunodeficiency, growth retardation, and microcephaly. The yeast of homolog of XLF is Nej1. XLF has been shown to interact with the XRCC4 x DNA-ligase IV complex and is implicated in the DNA religation step of the NHEJ pathway.
Alternate Names
non-homologous end-joining factor 1; nonhomologous end-joining factor 1; protein cernunnos; XLF; XRCC4-like factor
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.