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Rabbit anti-XPD Antibody Affinity Purified

bethyl
Bethyl Laboratories Catalog #
Validated
Target:
XPD
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
Between 710 and C-terminus
Isotype:
IgG
Conjugate:
Unconjugated
Purity:
Antigen Affinity Purified
100 µl (1000 µg/ml)

10 µl (1000 µg/ml)

$131.00 $464.00
Qty:

Product Details

Specifications

Verified Reactivity
Human
Antigen Species
Human
Concentration
1000 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
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Production Procedures
Antibody was affinity purified using an epitope specific to XPD immobilized on solid support.

The epitope recognized by A303-658A-T maps to a region between residue 710 and 760 of human Xeroderma Pigmentosum Complementary Group D, using the numbering given in entry NP_000391.1 (GeneID 2068).
Antibody was affinity purified using an epitope specific to XPD immobilized on solid support.

The epitope recognized by A303-658A maps to a region between residue 710 and 760 of human Xeroderma Pigmentosum Complementary Group D, using the numbering given in entry NP_000391.1 (GeneID 2068).

Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Country of Origin
USA

Additional Product Information

XPD (Xeroderma pigmentosum group D-complementing protein) is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. XPD has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in the XPD gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome [taken from NCBI Entrez Gene (Gene ID: 2068)].

2068
ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit
P18074
TFIIH basal transcription factor complex helicase XPD subunit

Alternate Names

basic transcription factor 2 80 kDa subunit; BTF2 p80; COFS2; CXPD; DNA excision repair protein ERCC-2; DNA repair protein complementing XP-D cells; EM9; excision repair cross-complementation group 2; TFIIH; TFIIH basal transcription factor complex 80 kDa subunit; TFIIH p80; TFIIH subunit XPD; TTD; TTD1; xeroderma pigmentosum complementary group D; XPD

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.