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Whitepaper: An end-to-end workflow for exploring spatial biology through multiplex IHCWhitepaperMultiplex immunohistochemistry (IHC) technologies are powerful tools to visualize multiple markers in the same tissue sample. These techniques, which include tyramide signal amplification and cyclic immunofluorescence, help scientists understand the cells that make up a tissue, what markers they express, their spatial distribution, and their potential interactions with one another. These methods depend on antibodies that are specific to the target, produce a clean signal, and have low background.
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Webinar: An end-to-end workflow for exploring spatial biology through multiplex IHCWebinarMultiplex immunohistochemistry (IHC) technologies are powerful tools to visualize multiple markers in the same tissue sample. These techniques, which include tyramide signal amplification and cyclic immunofluorescence, help scientists understand the cells that make up a tissue, what markers they express, their spatial distribution, and their potential interactions with one another. These methods depend on antibodies that are specific to the target, produce a clean signal, and have low background.
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Nanomolar VHH binders of PD-L1 and other therapeutic targets from the AbNano™ VHH Naive LibraryPosterVHH domains, derived from the variable heavy chain of the heavy-chain-only IgG2 and IgG3 domains in camelids, represent a small, single-domain antibody fragment. VHH domains have been successfully applied to technologies such as bispecific therapeutic molecules.
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Improving Antibody Purification for Veterinary MedicineArticleDogs and humans suffer from many common ailments, including cancer, degenerative joint disease, and atopic dermatitis. Antibody-based therapeutic options for these conditions offer hope for human patients, but translating human-centric approaches verbatim to veterinary medicine is rarely feasible. For example, Staphylococcus aureus-expressed protein A (SpA) strongly binds human immunoglobulin G (IgG), making it very useful for purifying therapeutic antibodies. However, it poorly binds most canine IgGs. Aiming to accelerate antibody-based therapeutic development in veterinary medicine, scientists from Hokkaido University demonstrated that the SpsQ protein expressed by the related bacterium Staphylococcus pseudintermedius can be used instead for canine antibody development.1
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Control Line Systems for Lateral Flow AssaysArticleLateral flow tests consist of a test line and a control line. The control line provides validation of a functioning test. If the control line does not appear after running the test, that test is deemed invalid. The choice of a control line antibody will depend on which detector antibody is used in the test.
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