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From Our Learning Center, Discover All Antibody Resources Including Webinars, eBooks, and Protocols.

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Fortis Life Sciences provides high-quality reverse transcription (RT) kits developed for reliable results in RT-PCR and RT-qPCR applications. Our solutions support cDNA synthesis and one-step RT-qPCR, enabling critical research in gene expression, pathogen detection, and diagnostic assay development.

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Advantages of Recombinant Monoclonal Antibodies over Hybridoma-Derived Antibodies

Recombinant monoclonal antibodies have emerged as a superior alternative to hybridoma-derived monoclonal antibodies, offering numerous advantages in antibody production and application. This article explores the benefits of recombinant techniques over traditional hybridoma methods, focusing on considerations such as reproducibility, scalability, storage, and the increasing role of recombinant antibodies in diagnostics and therapeutics. 

Resource Type

Field

Holliday junctions are a four-way DNA junction formed during replication fork regression, homology-dependent repair, and mitosis. Specifically, they are an intermediate of replication and form at the site of double-stranded DNA breaks.

Happy Hollidays!

Holliday junctions were discovered in 1964 by geneticist Robin Holliday to describe how gene-conversion events occur during meiosis in fungi. Holliday junctions are a four-way DNA junction formed during replication fork regression, homology-dependent repair, and mitosis. Specifically, they are an intermediate of replication and form at the site of double-stranded DNA breaks.

Research Area

PCDH19 mosaic mice help scientists decipher the neural underpinnings of developmental and epileptic encephalopathy 9.

Understanding Neuronal Network Activity in Developmental and Epileptic Encephalopathy 9

Developmental and epileptic encephalopathy 9 is a neurodevelopmental disorder caused by a mutation in PCDH19. Because disease only occurs in heterozygous PCDH19 individuals, scientists developed a mosaic mouse model where some cells express PCDH19 and others do not. This model helped them understand that PCDH19-negative neurons are hyperexcitable in a DEE9 mouse model and how the brain responds as a result.

Publication Date

Target

Applications

The discovery of monoclonal antibodies (mAbs) in 1975 heralded a remarkable breakthrough in precision medicine, opening up many doors for personalized diagnosis and care. Beyond healthcare, antibody technology is now essential for developing new tools to monitor the health of our environment, improve agricultural products, and build more resilient food sources. 

From Cancer to Crops: How Antibody Engineering is Changing Everything 

The discovery of monoclonal antibodies (mAbs) in 1975 heralded a remarkable breakthrough in precision medicine, opening up many doors for personalized diagnosis and care. Just over a decade later, in 1986, the FDA approved the first mAb product to prevent kidney transplant rejection.1 Since then, advances in mAb engineering have been monumental, fundamentally changing how we approach the treatment of cancer, infectious diseases, and autoimmune conditions. Beyond healthcare, antibody technology is now essential for developing new tools to monitor the health of our environment, improve agricultural products, and build more resilient food sources.

Related Products

Hospital-acquired pneumonia (HAP) is the most common cause of hospital-acquired infections in the US and Europe. Antibiotic use is a significant risk factor for HAP but the mechanisms involved in this risk factor remain poorly understood.  This recent study explored microbiome diversity and the impact of transplanting microbiota samples from antibiotic treated and antibiotic naive patients into wild type mice or those lacking short chain fatty acid (SCFA) receptors. These experiments highlighted the role of the naïve microbiota for inducing SCFAs that play a critical role in antimicrobial activity of inflammatory monocytes in the lung.

Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung

A multiplex point-of-care sensor detects amphetamine, cocaine, and benzodiazepine simultaneously from saliva samples.

Antibody-based sensors for multiplex point-of-care drug monitoring

To improve point-of-care drug detection, scientists developed a multiplex drug monitoring sensor that uses antibodies to bind amphetamine, cocaine, or benzodiazepine1. The binding of these drugs reduces the oxidation current in a concentration dependent manner where higher concentrations of the drug cause a greater decrease in oxidation current. The sensor is selective for these drugs as interferences from analgesics and other illicit drugs had minimal effects on the current change.

Research from Hilab demonstrates how to increase sensitivity of COVID-19 rapid tests, bringing the limit of detection of SARS-CoV-2 nucleocapsid protein from 7.5 ng/mL to 2.0 ng/mL.

Boosting lateral flow immunoassay sensitivity by increasing antigen-antibody interaction time and test line antibody concentration

Lateral flow immunoassays (LFIAs) are useful tools for point of care diagnostic testing. Improving their sensitivity can help prevent the spread of viruses like SARS-CoV-2 by detecting infections earlier. In effort of lowering the limit of detection of their COVID-19 rapid antigen test, scientists at Hilab have developed a rapid test prototype called “lateral flow intermembrane immunoassay test” that brings the limit of detection to 2.0 ng/mL of SARS-CoV-2 nucleocapsid protein1.