Rabbit anti-FANCD2 IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00624 maps to a region between residue 1401 and 1451 of human Fanconi anemia, complementation group D2 using the numbering given in entry NP_001018125.1 (GeneID 2177).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to FANCD2 immobilized on solid support.
The epitope recognized by IHC-00624-T maps to a region between residue 1401 and 1451 of human Fanconi anemia, complementation group D2 using the numbering given in entry NP_001018125.1 (GeneID 2177).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
FANCD2 (Fanconi anemia, complementation group D) is a protein involved in DNA repair. Defects in FANCD2 are the cause of Fanconi anemia, a heterogenous autosomal recessive disorder characterized by congenital malformations and a predisposition to cancer. The FANCD2 gene is one of 13 complementation groups that include FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, and FANCN/PALB2. The FANC members are not homologous proteins but are related by their assembly into a common nuclear complex.
Alternate Names
FA4; FACD; FAD; FAD2; FA-D2; FANCD; Fanconi anemia complementation group D2; Fanconi anemia group D2 protein; Protein FACD2
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.