Rabbit anti-NF2 IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00193 maps to a region between residues 550 and the C-terminus (residue 595) of human Neurofibromin 2 using the numbering given in entry NP_000259.1 (GeneID 4771). This epitope is common to NF2 isoforms 1 and 9 (Mer162). Antibody was affinity purified using an epitope specific to NF2 isoform1 immobilized on solid support.
The epitope recognized by IHC-00193-T maps to a region between residues 550 and the C-terminus (residue 595) of human Neurofibromin 2 using the numbering given in entry NP_000259.1 (GeneID 4771). This epitope is common to NF2 isoforms 1 and 9 (Mer162).
Additional Product Information
Mutations in NF2 (neurofibromin 2) are associated with neurofibromatosis type II which is characterized by Schwann cell tumors (schwannomas) which are benign slow-growing tumors that are resistant to chemotherapeutic intervention. NF2 is a membrane/cytoskeletal associated protein that has been classified as a novel type of tumor suppressor due to its function in membrane organization versus a classic tumor suppressor function that regulates cell cycle machinery.
Alternate Names
ACN; BANF; merlin; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2 (bilateral acoustic neuroma); Neurofibromin-2; SCH; schwannomerlin; schwannomin
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.