Bethyl Laboratories
Rabbit anti-NF2 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00193
TargetNF2
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC, IHC-IF
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Product Description
Mutations in NF2 (neurofibromin 2) are associated with neurofibromatosis type II which is characterized by Schwann cell tumors (schwannomas) which are benign slow-growing tumors that are resistant to chemotherapeutic intervention. NF2 is a membrane/cytoskeletal associated protein that has been classified as a novel type of tumor suppressor due to its function in membrane organization versus a classic tumor suppressor function that regulates cell cycle machinery.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 545 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
100 µg/ml
Target Identity
TargetNF2
Antigen Species
Human
Gene ID4771
Gene Symbol
NF2
Gene Name
neurofibromin 2
Uniprot IDP35240
Protein Name
Merlin
Product Information
Applications
IHC, IHC-IF
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to NF2 isoform1 immobilized on solid support.
The epitope recognized by IHC-00193 maps to a region between residues 550 and the C-terminus (residue 595) of human Neurofibromin 2 using the numbering given in entry NP_000259.1 (GeneID 4771). This epitope is common to NF2 isoforms 1 and 9 (Mer162).
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Immunohistochemistry-Immunofluoresence (IHC-IF)1:50 - 1:500
Documents
Safety Data SheetPDF · IHC-00193Open
Product DatasheetPDF · IHC-00193 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00193 · Lot 1 (current lot)Open
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