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Rabbit anti-ARMS Antibody Affinity Purified

bethyl
Bethyl Laboratories Catalog #
Validated
Target:
ARMS
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
Between 1425 and 1475
Isotype:
IgG
Conjugate:
Unconjugated
Purity:
Antigen Affinity Purified
100 µl (1000 µg/ml)

10 µl (1000 µg/ml)

$131.00 $464.00
Qty:

Product Details

Specifications

Verified Reactivity
Human
Antigen Species
Human
Concentration
1000 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
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Production Procedures
Antibody was affinity purified using an epitope specific to ARMS immobilized on solid support.

The epitope recognized by A303-002A maps to a region between residue 1400 and 1450 of human Ankyrin Repeat-Rich Membrane Spanning using the numbering given in entry NP_065789.1 (GeneID 57498).

Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Antibody was affinity purified using an epitope specific to ARMS immobilized on solid support.

The epitope recognized by A303-002A-T maps to a region between residue 1400 and 1450 of human Ankyrin Repeat-Rich Membrane Spanning using the numbering given in entry NP_065789.1 (GeneID 57498).
Country of Origin
USA

Additional Product Information

Ankyrin repeat-rich membrane-spanning protein (ARMS) is also known as Kinase D-interacting substrate of 220 kDa (KIDINS220). ARMS Promotes prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Arms may play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. ARMS may play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. ARMS has also been shown to modulate stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9ULH0].

57498
KIDINS220
kinase D interacting substrate 220
Q9ULH0
Kinase D-interacting substrate of 220 kDa

Alternate Names

ankyrin repeat-rich membrane-spanning protein; ARMS; kinase D-interacting substrate 220kDa; kinase D-interacting substrate of 220 kDa; SINO

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.