Rabbit anti-CD25/IL-2R alpha Recombinant Monoclonal Antibody [BLR158J]
Product Details
Specifications
Request Formulation Change Borate Buffered Saline (BBS) pH 8.2 with 0.09% Sodium Azide, BSA-Free
Request Formulation Change
Immunogen was a peptide representing a region between residue 222 and the C-terminus (residue 272) of human Interleukin-2 receptor subunit alpha (aka CD25) using the numbering given in entry NP_000408.1 (Gene ID 3559).
Additional Product Information
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. The IL2 receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. [taken from NCBI Entrez Gene (Gene ID: 3559)].
Alternate Names
CD antigen CD25; CD25; IDDM10; IL-2 receptor subunit alpha; IL2R; IL-2R subunit alpha; IL-2-RA; IL2-RA; IMD41; interleukin 2 receptor, alpha; interleukin-2 receptor subunit alpha; p55; TAC antigen; TCGFR