Rabbit anti-GITR/TNFRSF18 Recombinant Monoclonal Antibody [BLR068G]
Product Details
Specifications
Immunogen was a peptide representing a region between residue 191 and the C-terminus (residue 241) of human Tumor necrosis factor receptor superfamily member 18 (GITR) using the numbering given in entry NP_004186.1 (Gene ID 8784).
Additional Product Information
GITR/TNFRSF18 is a member of the TNF-receptor superfamily. It has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by regulatory T cells. GITR/TNFRSF18 also plays a role in the regulation of CD3-driven T-cell activation and programmed cell death. [provided by RefSeq, Feb 2011] [taken from NCBI Entrez Gene (Gene ID: 8784)].
Alternate Names
activation-inducible TNFR family receptor; AITR; CD antigen CD357; CD357; GITR; GITR-D; glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation-inducible protein; tumor necrosis factor receptor superfamily member 18
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).
Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.