Rabbit anti-PALB2 Recombinant Monoclonal Antibody [BLR339M]
Product Details
Specifications
Immunogen was a peptide representing a region between residue 350 and 400 of human Partner and localizer of BRCA2 (aka PALB2) using the numbering given in entry NP_078951.2 (Gene ID 79728).
Additional Product Information
PALB2 (partner and localizer of BRCA2) interacts with BRCA2 and promotes BRCA2 localization and stability. PALB2 is also known as FANCN. Bi-allelic mutations in PALB2 result in Fanconi anemia disorder and breast cancer susceptibility. At the cellular level, PALB2 is important to the DNA damage response and chromosome stability and is essential to BRCA2 function.
Alternate Names
FANCN; mutant partner and localizer of BRCA2; partner and localizer of BRCA2; PNCA3
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent.
Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (A120-101P).
Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (A120-113P) with 5% Normal Pig Serum (S100-020) added to the blocking buffer.