Rabbit anti-PPP1CB IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00484 maps to a region between residue 280 and the C-terminus (residue 327) of human Protein Phosphatase 1, Catalytic Subunit, Beta Isoform using the numbering given in entry NP_996759.1 (GeneID 5500).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to PPP1CB immobilized on solid support.
The epitope recognized by IHC-00484-T maps to a region between residue 280 and the C-terminus (residue 327) of human Protein Phosphatase 1, Catalytic Subunit, Beta Isoform using the numbering given in entry NP_996759.1 (GeneID 5500).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
Protein phosphatase 1 (PP1) is a major eukaryotic serine/threonine phosphatase that is involved in a multitude of cellular functions. PP1 is a holoenzyme that consists of the PP1 catalytic subunit (PP1c) that associates with and is regulated by over 50 regulatory subunits. There are several gene and alternative splice products of the catalytic subunit PP1c. PPP1CB encodes the PP1 beta catalytic subunit. In addition to PP1 beta, there are two splice variants of PP1 alpha (PPP1CA), and PP1 gamma (PPP1CC). The mutually exclusive interaction between the various catalytic and regulatory subunits allows the PP1 enzyme to be involved in a variety of functions which include cell division, glycogen metabolism, muscle contractility, and protein synthesis. serine/threonine-protein phosphatase PP1-beta catalytic subunit, PP-1B, PPP1CD, MGC3672.
Alternate Names
epididymis secretory sperm binding protein Li 80p; HEL-S-80p; NSLH2; PP1B; PP-1B; PP1beta; PPP1CD; protein phosphatase 1, catalytic subunit, beta isoform; protein phosphatase 1, catalytic subunit, beta isozyme; protein phosphatase 1, catalytic subunit, delta isoform; protein phosphatase 1-beta; protein phosphatase 1-delta; serine/threonine-protein phosphatase PP1-beta catalytic subunit
Applications
Epitope exposure is recommended.
Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.