Rabbit anti-XPC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by A301-122A maps to a region between residue 890 and 940 of human xeroderma pigmentosum, complementation group C using the numbering given in entry NP_004619.2 (GeneID 7508).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to XPC immobilized on solid support.
The epitope recognized by A301-122A-T maps to a region between residue 890 and 940 of human xeroderma pigmentosum, complementation group C using the numbering given in entry NP_004619.2 (GeneID 7508).
Additional Product Information
Defects in XPC are a cause of xeroderma pigmentosum complementation group C, a rare autosomal recessive diseased characterized by hypersensitivity to sunlight and an elevated risk of skin cancer on sun-exposed areas. XPC is involved in nucleotide excision repair and performs its function as part of a heterodimeric complex with HHR23B. XPC has been found to play a role in the early stages of repair that involve incising damaged DNA.
Alternate Names
DNA repair protein complementing XP-C cells; mutant xeroderma pigmentosum group C; p125; RAD4; Xeroderma pigmentosum group C-complementing protein; xeroderma pigmentosum, complementation group C; XP3; XPCC
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).
Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.